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Fever, allergic reactions, myelotoxicity and myalgia are also possible Chemistry Prepared from genetically engineered cultures of E. Human interferon alfa is a complex protein that contains or amino acids.

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Do not expose solutions to room temperature for longer than 24 hours. Do not vigorously shake solutions.

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An article proposing using this product in cats for the treatment of FeLV states that after dilution of 3 million IU in one liter of sterile saline the resultant solution remains active for years if frozen or for months if refrigerated.

However, data corroborating this is apparently not available.

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Pharmacology The pharmacologic effects of the interferons are widespread and complex. Suffice it to say, that interferon alfa has antiviral, antiproliferative and immunomodulating effects.

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Its antiproliferative and antiviral activities are thought to be due to its effects on the synthesis of RNA, DNA, and cellular proteins oncogenes included. The mechanisms for its antineoplastic activities are not well understood, but are probably related these effects as well. However, studies published at this point have not been controlled and the usefulness giardia treat yard these agents after oral administration is in question. More clinicians are suggesting that it may be useful at higher dosages when given parenterally for a variety of conditions see dosage section.

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Toxicities and high megsemmisiteni a fergeket costs may limit usefulness. Oral interferon may also be of benefit in the treatment of ocular giardia treat yard infection, but controlled studies need to be performed to document safety and efficacy.

Feline interferon-omega has recently become available in several countries and it may become significantly useful in treating viral diseases in bioth cats and dogs.

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Pharmacokinetics Interferon alfa is poorly absorbed after oral administration due to its degradation by proteolytic enzymes and studies have not gyors opioid méregtelenítés vagyok measurable levels in the systemic circulation.

However, there may be some absorption via upper GI mucosa.

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Interferon alfa is widely distributed throughout the body, although it does not penetrate into the CNS well. It is unknown if it crosses the placenta.

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Interferon alfa is freely filtered by the glomeruli, but is absorbed by the renal tubules where it is metabolized by brush border or lysosomes. Hepatic metabolism is giardia treat yard minor importance.

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The plasma half-life in cats has been reported as 2. In humans, the FDA categorizes this drug as category C for use during pregnancy Animal studies have shown an adverse effect on the fetus, but there are no adequate studies in humans; or there are no animal reproduction studies and no adequate studies in humans.

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It is not known whether this giardia treat yard is excreted in milk. Higher dosages given parenterally may cause malaise in cats. Fever, allergic reactions, myelotoxicity and myalgia are also possible in cats.

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Cats given human interferon-alfa parenterally may develop significant antibodies to it after weeks of treatment. Determine dosages carefully.

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Drug Interactions Additive or synergistic antiviral effects may occur when interferon alfa is used in conjunction with zidovudine AZT or acyclovir. This effect does not appear to occur with vidarabine, although increased toxicities may occur.

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The veterinary significance of these potential interactions is unclear. Treat alternate weeks or continuously. Greene and Watson Doses — Cats 1. Little in the way of large, controlled trials to determine which, if any, immunomodulating therapies interferon or other agentsare likely to benefit FeLV-infected cats.

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Levy For treatment of FIV-infected cats: 1. For chronic infections: 30 U cat PO daily; 7 days on —7 giardia treat yard off; repeat cycle.

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Giardia treat yard 2. Treat alternate weeks. Divide giardia treat yard aliquots of either 1 or 10 ml and freeze. Take 0.